Yancheva D.Cherneva E.Quick M.Mikhova B.Shivachev B.Nikolova R.Djordjevic A.Untergehrer M.Jürgenliemk G.Kraus B.Smelcerovic A.2024-07-102024-07-102024-07-102024-07-102015-01-011318-020710.17344/acsi.2015.1418SCOPUS_ID:84943178048https://rlib.uctm.edu/handle/123456789/347Three novel N-(α-bromoacyl)-α-amino esters: methyl 2-(2-bromo-3-methylbutanamido)pentanoate (1), methyl 2-(2-bromo-3-methylbutanamido)-2-phenylacetate (2) and methyl 2-(2-bromo-3-methylbutanamido)-3-phenylpropanoate (3) were synthesized. Single crystal X-ray diffraction data are reported for compounds 1 and 2. The cytotoxicity, antiinflammatory and antibacterial activity of compounds 1-3 were investigated. Additionally, the physico-chemical properties of studied compounds were calculated and an in silico toxicological study of compounds 1-3 was performed. The low level of cytotoxicity and absence of antibacterial and anti-inflammatory activity of 1-3 in tested concentrations might be a beneficial prerequisite for their incorporation in prodrugs.enArticle