Marinov M.Kostova I.Naydenova E.Stoyanov N.2024-07-162024-07-162024-07-162024-07-162021-01-011314-79781314-7471SCOPUS_ID:85101552632https://rlib.uctm.edu/handle/123456789/1309Imidazolidine-2,4-diones (hydantoins and spirohydantoins) and nalidixic acid (1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid) are heterocyclic compounds whose ring structures include nitrogen atoms. These substances exhibit potent pharmacological activity as antitumor, antibacterial and antifungal agents, as well as aldose reductase inhibitors. This article presents the synthesis of novel heterocyclic compounds, based on the interaction of imidazolidinediones with nalidixic acid. The imidazolidinedione derivatives obtained were characterized by physicochemical parameters, elemental analysis, IR, 1H and 13C NMR spectral data. The biological activity of the synthesized products was evaluated against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the mold Aspergillus brasiliensis. All compounds showed activity against the Gram-positive and Gram-negative bacteria tested.enArticle