SYNTHESIS, ISOLATION AND BIOLOGICAL ACTIVITY STUDIES OF GALANTHAMINE DERIVATIVES INCLUDING PEPTIDE MOIETY AND TANNINS FROM MEDICINAL PLANTS

Atanasov A.Karadjova V.Andonova A.Tsekova D.Lozanov V.Parashkevova B.Mindov I.Todorova R.Vezenkov L.2024-07-162024-07-162024-07-162024-07-162022-01-011314-79781314-7471SCOPUS_ID:85123889311https://rlib.uctm.edu/handle/123456789/1347The search of a new chemical substances influencing platelet aggregation is a very important endeavor for medical practice. Among the compounds that have antiaggregating activity are some peptides, tannins, etc. Here we present antiaggregation activity of Arg-Gly-Asp (RGD) peptide derivatives. Synthetic procedures of new peptide-galantamine derivatives including also glucose moiety designed to possess such activity are included. The in vitro effect of water extract from 20 tannins-containing plants from Bulgarian flora on aggregation of modified rat platelet-rich plasma was investigated and seven of them (Corylus avellana L, Cydonia oblonga Mill, Dryopteris filix-mas (L.) Schott, Ephedra distachya L., Geum urbanum L., Primula officinalis (L.) Hill and Punica granatum L.)were able to inhibit platelet aggregationenSYNTHESIS, ISOLATION AND BIOLOGICAL ACTIVITY STUDIES OF GALANTHAMINE DERIVATIVES INCLUDING PEPTIDE MOIETY AND TANNINS FROM MEDICINAL PLANTSArticle