Vladkova T.G.Martinov B.L.Gospodinova D.N.2024-07-162024-07-162024-07-162024-07-162023-01-011314-79781314-7471SCOPUS_ID:85160417913https://rlib.uctm.edu/handle/123456789/1427Microbial biofilm forms on any living or non-living material surface contacting with microbial species. It is a persistent world-weight spread problem with very high prize. This explains the exclusive interest to development of anti-biofilm material surfaces. The continuously increasing microbial resistance to currently used antimicrobial agents requires looking for new ones. Marine biota is a rich source of biologically active substances with anti-biofilm potential that is scarily studied. The aim of this review is to outline the variety of marine sources delivering antimicrobial agents and their ability to inhibit different stages of the biofilm development, expecting to give some ideas for their utilization in the creation of improved antibiofilm material surfaces. It includes short information about the negative impact and cost, mode of development and composition of the microbial biofilms, as well as principle approaches to the inhibition with focus on the sources of biologically active substances and anti-biofilm agents from marine biota. The main conclusion is that the antibiofilm activity of many marine biota derived biologically active substances is not enough investigated although their strong bactericidal, antioxidant, surfactant and other activities are already proved and utilized in the medicine, cosmetic, food industry and others. This review is an update of the known to day on the marine sources derived anti-biofilm agents.enArticle