Kushev D.Maneva L.Grancharov K.Spassovska N.Naydenova E.Popova J.2024-07-102024-07-102024-07-102024-07-102003-01-010939-507510.1515/znc-2003-1-218SCOPUS_ID:0041696134https://rlib.uctm.edu/handle/123456789/87Four new platinum(II) complexes of 3-aminocyclopentanespiro-5-hydantoin (acpsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were synthesized and characterized by elemental analysis, IR and 1NMR spectra. The spectral analyses indicated a cis-square planar structure of the complexes with ligands coordinated via the NH2 group. The complexes were evaluated for in vitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N, using cell-growth and macromolecular synthesis assay. The compounds, with exception of [Pt(NH3)(achpsh)Cl2] (IV), exhibited much lower cytotoxicity than that of cisplatin (DDP). Compound IV was nearly as cytotoxic as DDP. The new complexes exerted low antibacterial activity as assessed by seven bacterial strains. © 1946–2014, Verlag der Zeitschrift für Naturforschung. All rights reserved.enArticle