Georgieva S.Todorov P.Wesselinova D.2024-07-102024-07-102024-07-102024-07-102014-01-011631-074810.1016/j.crci.2014.01.020SCOPUS_ID:84910070422https://rlib.uctm.edu/handle/123456789/320Novel mixed complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were synthesized and their in vitro anticancer activity was investigated. The structures of the compounds were confirmed by IR, UV-Vis spectrometry, voltammetry and elemental analysis. The cytotoxic effects of novel complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT29, MDA-MB-231, HepG2 and HeLa cell lines after 24 h of treatment. The most sensitive cells were the HepG2 cells at various concentrations of both tested compounds followed by HT29.enArticle