Browsing by Author "Anchev B."

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    On the synthesis, surface activity and supramolecular structures of pseudo double-chained L-Asp based amphiphiles
    (2020-01-01) Anchev B.; Grozev N.A.; Mircheva K.M.; Tsekova D.S.
    Eight new final compounds derivatives of L-Asp are synthesized. They contain L-Asp linked by an amide bond both to n-hexyl chain on its C-side and an acyl chain linked to the N-side. Four different acylic residues are condensed to the N side. The newly synthesized compounds belong to two series of structures, as four of them contain L-Asp-b-benzyl ester, while the other four-a typical L-Asp-b-carboxylic group. The structures of the surfactants are categorized as pseudo-double alkyl chained amphiphiles, because one of the tails has a constant length of only six carbon atoms. Some of the newly synthesized surfactants are studied as monolayers on the air/water interface. The properties of the rest of them are determined by tensiometric and conductometric methods. Nano-and micro-sized supramolecular complexes of the compounds studied are observed in monolayers using Brewster Angle Microscopy (BAM) and Scanning Electron Microscopy (SEM) for samples after solvent evaporation.
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    pH-dependent hydrogels obtained by low molecular weight derivatives of aspartic acid and glutamic acid (L-Asp and L-Glu)
    (2024-01-01) Tsekova D.; Kondova V.; Dochev K.; Anchev B.
    We report here the synthesis of two new anionic gemini surfactants, derivatives of L-Asp and L-Glu with analogous structure and their applications as low molecular weight gelators. Conditions for formation of pH-dependent hydrogels and their stability are presented and discussed. Although both compounds possess very close molecular structures, only one of them – the derivative of L-Asp, can form stable hydrogels. Loading of such a hydrogel with silver nanoparticles and the conditions of their release are also studied and described. Different methods to analyze molecular and supramolecular structures, such as NMR, FTIR, UV–VIS and SEM, are used to characterize the compounds and also to understand and follow the processes of loading and release of silver nanoparticles. It was found that a stable hydrogel can be formed only in acidic solution, while release can happen only at basic condition – over pH ≥ 9. The results obtained show that such pH-dependent hydrogels can be used for slowly and gradually supply of active compounds at necessity, expressed through changing the pH of the living tissue.