Browsing by Author "Karamancheva I."

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    Application of Fourier transform infrared spectroscopy for tumor diagnosis
    (2013-12-31) Simonova D.; Karamancheva I.
    The absence of sufficient reliable methods for early detection of cancers requires a search for new and more effective techniques for screening and prevention. The discovery and introduction of appropriate techniques to test risk groups would increase the chances of successful treatment and subsequently reduce mortality. Accurate diagnostic tests and minimally invasive procedures are a main requirement for cost-effective screening tests. Fourier transform infrared spectroscopy (FTIR) is a non-invasive technology and can detect changes in a functional group in molecules from tissues or cells. The changes can be visualized by a spectrum of wavenumbers in the mid infrared range (4000 to 400 cm-1). FTIR has shown promises as a sensitive diagnostic tool to distinguish malignant from normal cells in cancers including tumors of colon, ovaries, breast, skin, cervix, lung and oesophagus. The biochemical changes are often observed between tumor and normal cells within a wavenumber range known as the ``fngerprint region`` (encompassing 1800 to 950 cm-1). The aim of this review is to summarize the application of FTIR for diagnosis of different types of cancer cells. © Biotechnol. & Biotechnol.
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    Directed modification of the properties of vacuum deposited polymer layers by energy-stimulated processes
    (2008-05-01) Dimov D.; Spassova E.; Georgiev A.; Karamancheva I.; Assa J.; Danev G.
    Vacuum deposited thin layers were investigated for obtaining nanocomposite films based on a polyimide matrix and copper phthalocyanine particles as ``guests``. The paper presents a study related to energy-stimulated processes using microwave treatment as an alternative to the classical thermal processing. FTIR spectroscopy investigations demonstrated the possibility for a considerable shortening of the entire treatment process. The best results were obtained by combining the thermal and microwave treatments (15 min microwave + 15 min thermal treatment). © 2008 IOP Publishing Ltd.