Browsing by Author "Lozanov V."

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    SYNTHESIS AND SPECTRAL PROPERTIES OF PALLADIUM (II) COMPLEX OF 1,4-PHENYLENE-BIS(N-1,10-PHENANTHROLYNYLMETHANIMINE)
    (2022-01-01) Neykov M.; Lozanov V.
    The synthesis of 1,4-phenylene-bis(N-1,10-phenanthrolynylmethanimine) and its Pd (II) complex is described. Their structures were confirmed using FTIR, 1H-NMR, MS, UV-Vis and ICP-OES. Based on these analysis, it can be concluded that the obtained complex is a linear coordination polymer.
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    SYNTHESIS, ISOLATION AND BIOLOGICAL ACTIVITY STUDIES OF GALANTHAMINE DERIVATIVES INCLUDING PEPTIDE MOIETY AND TANNINS FROM MEDICINAL PLANTS
    (2022-01-01) Atanasov A.; Karadjova V.; Andonova A.; Tsekova D.; Lozanov V.; Parashkevova B.; Mindov I.; Todorova R.; Vezenkov L.
    The search of a new chemical substances influencing platelet aggregation is a very important endeavor for medical practice. Among the compounds that have antiaggregating activity are some peptides, tannins, etc. Here we present antiaggregation activity of Arg-Gly-Asp (RGD) peptide derivatives. Synthetic procedures of new peptide-galantamine derivatives including also glucose moiety designed to possess such activity are included. The in vitro effect of water extract from 20 tannins-containing plants from Bulgarian flora on aggregation of modified rat platelet-rich plasma was investigated and seven of them (Corylus avellana L, Cydonia oblonga Mill, Dryopteris filix-mas (L.) Schott, Ephedra distachya L., Geum urbanum L., Primula officinalis (L.) Hill and Punica granatum L.)were able to inhibit platelet aggregation