Browsing by Author "Mishra A.P."

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    Bioactive compounds and health benefits of Artemisia species
    (2019-01-01) Nigam M.; Atanassova M.; Mishra A.P.; Pezzani R.; Devkota H.P.; Plygun S.; Salehi B.; Setzer W.N.; Sharifi-Rad J.
    Artemisia L. is a genus of small herbs and shrubs found in northern temperate regions. It belongs to the important family Asteraceae, one of the most numerous plant groupings, which comprises about 1000 genera and over 20000 species. Artemisia has a broad spectrum of bioactivity, owing to the presence of several active ingredients or secondary metabolites, which work through various modes of action. It has widespread pharmacological activities and has been used as traditional medicine since ancient times as an anthelmintic, antispasmodic, antirheumatic, and antibacterial agent and for the treatment of malaria, hepatitis, cancer, inflammation, and menstrual-related disorders. This review comprises the updated information about the ethnomedical uses and health benefits of various Artemisia spp. and general information about bioactive compounds and free radicals.
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    Comparative evaluation of polyphenol contents and antioxidant activities between ethanol extracts of vitex negundo and vitex trifolia L. Leaves by different methods
    (2017-12-01) Saklani S.; Mishra A.P.; Chandra H.; Atanassova M.S.; Stankovic M.; Sati B.; Shariati M.A.; Nigam M.; Khan M.U.; Plygun S.; Elmsellem H.; Suleria H.A.R.
    The in vitro antioxidant potential assay between ethanolic extracts of two species from the genus Vitex (Vitex negundo L. and Vitex trifolia L.) belonging to the Lamiaceae family were evaluated. The antioxidant properties of different extracts prepared from both plant species were evaluated by different methods. DPPH scavenging, nitric oxide scavenging, and β-carotene-linoleic acid and ferrous ion chelation methods were applied. The antioxidant activities of these two species were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and Ethylene diamine tetra acetic acid (EDTA). Both species of Vitex showed significant antioxidant activity in all of the tested methods. As compared to V. trifolia L. (60.87-89.99%; 40.0-226.7 µg/mL), V. negundo has been found to hold higher antioxidant activity (62.6-94.22%; IC50 = 23.5-208.3 µg/mL) in all assays. In accordance with antioxidant activity, total polyphenol contents in V. negundo possessed greater phenolic (89.71 mg GAE/g dry weight of extract) and flavonoid content (63.11 mg QE/g dry weight of extract) as compared to that of V. trifolia (77.20 mg GAE/g and 57.41 mg QE/g dry weight of extract respectively). Our study revealed the significant correlation between the antioxidant activity and total phenolic and flavonoid contents of both plant species.
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    Phytochemical contents in solid-liquid extraction of aqueous alcoholic extract of chicory (cichorium intybus l.) leaves
    (2016-01-01) Dzharov V.V.; Mishra A.P.; Shariati M.A.; Atanassova M.S.; Plygun S.
    The object of our current study is to study the phytochemicalc contents in solid-liquid extraction of chicory (Cichorium intybus L.) dry leaves grown in Bulgaria. Cichorium intybus, commonly known as chicory, is well known as a coffee substitute but is also discretely used as the natural product in food industry and medicine throughout its long history. Solid-liquid extraction was performed by using the 50% aqueous ethanol for 120 min which results in concentration of phytochemical contents and the findings of our present results are well consistent with those obtained in other works. The chicory leaves were analysed for the content of tannin by titrimetric method; rutin was determined spectrophotometrically by using ammonium molybdate; the total phenolics was determined by the Folin-Ciocalteu assay and the total flavonoids was identified through the colorimetric reaction with aluminum (III) chloride. The content of total phenolics and total flavonoids of chicory varied between 2.71 mg GAE/mL for 10 min and 5.65 mg GAE/mL for 120 minutes and 0.84 mg CE/mL for 10 minutes and 2.45 mg CE/mL for 120 min. The content of rutin and tannins that varied within 0.71 percent for 10 minutes and 1.39 percent for 120 min of rutin and tannins was higher than that in 50% aqueous ethanol extract of Cichorium intybus L. for 120 min at 1.56% and 1.08% for 10 min, respectively. Extracts obtained positively correlated with their phenolic and flavonoid contents, rutin and tannins, respectively. Therefore, the complex of phytochemical active substance in dry leaves of Cichorium intybus L. offers lots of opportunities for future application in herbal medicine and nutrition industry to produce healthy food.