Browsing by Author "Nikolov Y."

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    Effects of aflatoxin B1 alone or co-administered with mycotox NG on performance and humoral immunity of Turkey broilers
    (2017-01-01) Valchev I.; Marutsova V.; Zarkov I.; Ganchev A.; Nikolov Y.
    The contamination of poultry feeds with aflatoxins is a global problem responsible for considerable losses to poultry industry. The aim of the present investigation was to evaluate the effects of aflatoxin B1 and Mycotox NG, applied either independently or together, on performance, relative weights of visceral organs and antibody titres against Newcastle disease in turkey broilers. Experiments of 42-day duration were carried out with sixty 7-day-old female turkey broilers (meat TM strain) divided into one control and five treatment groups (n=10): Group І - control (fed standard feed according to the species and age of birds); Group II - experimental, whose feed was supplemented with 0.5 g/kg Mycotox NG, Group II - experimental, whose feed contained 0.2 mg/kg aflatoxin B1, Group IV - experimental, whose feed contained 0.4 mg/kg aflatoxin B1, Group V - experimental, supplemented with 0.2 mg/kg aflatoxin B1 and 0.5 g/kg Mycotox NG and Group VI - experimental, supplemented with 0.4 mg/kg aflatoxin B1 and 0.5 g/kg Mycotox NG. In Groups III and IV, production traits (live body weight, daily weight gain, feed intake) as well as antibody titres were reduced along with increased feed conversion and relative weights of liver, kidneys, heart, pancreas, proventriculus and gizzard. At the same time, relative weights of the spleen, thymus and bursa of Fabricius were statistically significantly lower. The supplementation of the feed of Groups V and VI with 0.5 g/kg Mycotox NG reduced and prevented some of deleterious effects of AFB1 on production traits, antibody titres and relative weights of visceral organs.
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    Investigations on liver function in mulards with experimentally induced aflatoxicosis
    (2014-01-01) Groseva N.; Valchev I.; Binev R.; Kanakov D.; Hristov T.; Lazarov L.; Uzunova K.; Nikolov Y.
    Ducklings are among the most sensitive avian species to the toxic effects of aflatoxin .,B1 (AFB1). In this experiment, the toxic effects of AFB1 on liver morphology, blood plasma aspartate amino-transferase (AST), alanine amino-transferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), γ-glutamyltransferase (γ-GT), albumin, blood glucose, and plasma total protein (TP) were established in mulard ducks. The experiment was carried out with four groups of 20 10-day-old ducklings each. Each group included three subgroups with 10 birds. The groups were as followed: group - control (which received standard feed according to the species and age), group - experimental, which received compound feed with 0.5 mg/kg AFB1, group I receiving compound feed supplemented with 0.8 mg/kg AFB1 and group IV . compound feed supplemented with 0.5 mg/kg AFB1 and 2g/kg Mycotox NG. The experiment lasted for 42 days. Macroscopically, livers were enlarged, rounded, with yellowish colour and a frail consistency in group and I. Histopathologically, a various extent of dystrophy was detected depending on the dose of ingested toxin. The supplementation of compound feed with the mycosorbent Mycotox NG improved deviations in blood biochemical parameters and substantially reduced the severity and prevalence of histological lesions.