Browsing by Author "Petrov A."

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    Before or after mild acute heat exposure - does it matter for the therapy?
    (2025-01-01) Suleymanoglu Y.; Borisova B.; Danalev D.; Petrov A.; Tafradjiyska R.; Nocheva H.
    Adaptation to elevated temperatures poses a challenge that involves large-scale metabolic changes. It also affects the pharmacokinetics and pharmacodynamics of exogenous substances. Our experiments clearly showed differences in paw pressure thresholds in rats intraperitoneally injected with TDIFELLK-a C-terminal fragment of the calcium-binding, spermatid-specific protein 1- before and after exposure to 38.5 ± 0.5°C, compared to administration at 22 ± 2°C. Similarly, the analgesic effect of the substance, following antagonism of key analgesic receptors-namely opioid, cannabinoid, and serotonergic-was differentially influenced by heat exposure at normal temperature. The administration of the substance before heat exposure exerted a stronger effect than administration after heat exposure.