Browsing by Author "Petrova S."

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    Controlled synthesis of AB2 amphiphilic triarm star-shaped block copolymers by ring-opening polymerization
    (2009-12-01) Petrova S.; Riva R.; Jérôme C.; Lecomte P.; Mateva R.
    This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic poly(ε-caprolactone) (PCL). A series of AB2 triarm star-shaped copolymers with different molecular-weights for the PCL block were successfully synthesized by a three-step procedure. α-Methoxy-ω-epoxy-poly(ethylene oxide) (PEO-epoxide) was first synthesized by the nucleophilic substitution of α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) on epichlorohydrin. In a second step, the α-methoxy-ω,ω′-dihydroxy-poly(ethylene oxide) (PEO(OH)2) macroinitiator was prepared by the selective hydrolysis of the ω-epoxy end-group of the PEO-epoxide chain. Finally, PEO(OH)2 was used as a macroinitiator for the ring-opening polymerization (ROP) of ε-caprolactone (εCL) catalyzed by tin octoaote (Sn(Oct)2). PEO-epoxide, PEO(OH)2 and the AB2 triarm star-shaped copolymers were assessed by 1H NMR spectroscopy, size exclusion chromatography (SEC) and MALDI-TOF. The behavior of the AB2 triarm star-shaped copolymer in aqueous solution was studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). © 2009.
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    SYNTHESIS OF FLUORENATED ANALOGUES OF SELF-ASSEMBLING PEPTIDE P11-4 AND STUDY ON P11-4 THERAPEUTIC EFFECT ON ARTIFICIAL INITIAL ENAMEL LESIONS
    (2023-01-01) Uzunova I.; Dobrev I.; Danalev D.; Raycheva R.; Georgiev K.; Petrova S.; Nihtianova T.; Belcheva A.
    Treatment of artificial initial enamel lesions is a key process in the dental practice. Unfortunately, traditional methods are often not accepted well by the patients, especially by the children. In this reason the search for new more acceptable approaches is a long-sought approach. The selection of an appropriate and accurate protocol to treat white spot lesions as well as reliably monitoring of the lesion dynamics is crucial to avoid the need for further operative treatment. Herein, we report synthesis of two fluorinated analogues of the peptide P11-4 and creation of a protocol to compare the effect of self-assembling peptide P11-4 (CURODONT Repair) on artificial enamel lesions on smooth surfaces after pH-cycling in a bioreactor system. The assessment of the effect is done using surface microhardness investigation. A well working protocol for studying of therapeutic effect of peptides on artificial initial enamel lesions was created. The obtained experimental data reveals that the treatment of artificial lesions with self-assembling peptide P11-4 using a newly created protocol and selected methodology resulted in improved surface microhardness in the experimental group.