Browsing by Author "Velkov Z."
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Item SYNTHESIS, STRUCTURE AND PROOXIDANT ACTIVITY OF 3-HYDROXYFLAVONE COMPLEXES WITH Cu(II)(2022-01-01) Vakarelska-Popovska M.; Karadjova V.; Velkov Z.Hydroxyflavones chelate iron and copper ions thus preventing the formation of new active radicals in experiments in vivo. Furthermore, it is reported that some of them demonstrate in vitro prooxidant activity in the presence of metal ions. Consequently, there is no unanimity in the literature on the chemical mechanisms that engender the properties of these compounds vital for the human health. Herein, our investigations on the synthesis and DPPH activity of 3-hydroxyflavone complexes with copper ions obtained at different pH and different metal/ligand ratio are presented. Their structure was confirmed using spectral methods and elemental analyzes. A DFT quantum chemical study on the complexes structure was also performed. The resulting complexes were tested for activity against DPPH. The outcome show that the complexes exhibit prooxidant rather than antioxidant activity, which decreases with declining the relative metal ion content in the complexes.