Browsing by Author "Miloshev S."

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    PREPARATION OF GOLD LOADED MICELLES BASED ON POLY (ETHYLENE GLYCOL) - b - POLY (4-VINYL PYRIDINE) COPOLYMERS AS A TOOL FOR BIOMEDICAL APPLICATIONS
    (2017-01-01) Vircheva S.; Bryaskova R.; Miloshev S.; Tzoneva R.; Dishovsky N.
    Well-defined block copolymers based on poly (ethylene glycol) monomethyl ether and poly (4-vinyl pyridine) (PEG-b-P4VP) were prepared by atom transfer radical polymerization (ATRP). PEG-b-P4VP block copolymer self assembled in an aqueous medium with formation of nanosized spherical micelles was thus prepared. Gold nanoparticles were successfully loaded into PEG-b-P4VP based micelles. This was confirmed by UV-vis, TEM and DLS analysis. The cytotoxicity of gold loaded micelles against MDA-MB-231 breast cancer cells and L929 fibroblasts was determined.
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    Synthesis and characterization of diblock copolymers based on poly (ethylene glycol) and poly (4-vinyl pyridine) via atom transfer radical polymerization
    (2015-01-01) Vircheva S.; Bryaskova R.; Miloshev S.; Dishovsky N.
    Atom transfer radical polymerization (ATRP) was applied for the preparation of block copolymers based on poly (ethylene glycol) monomethyl ether and poly (4-vinyl pyridine) (MeOPEG-b-P4VP). This was achieved using chloro-terminated PEG as a macroinitiator. Further, the ATRP was performed using 4-VP as a second forming block in the presence of CuCl/PMDETA as a catalyst system. The successful formation of MeOPEG-b-P4VP block copolymers was proved by 1H NMR with the presence of all characteristic signals arising from PEG and 4-VP units. The GPC results showed the preparation of well-defined block copolymers with low dispersity, which confirms the controlled character of radical polymerization. The thermal properties of thus prepared copolymers were characterized by TGA analysis.