Browsing by Author "Neykov M."

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    Antioxidant capacity of 1,10-phenanthroline, 5-amino-1,10-phenanthroline and their Pd-Complexes
    (2017-01-01) Neykov M.; Kaloyanov N.; Mihailova B.; Goshev I.
    The present study describes the antioxidant activity of 1,10-phenanthroline, 5-amino-1,10-phenanthroline and their Pd complexes: Pd(5-NH2-phen)2(NO3)2 and Pd(phen)(NO3)2(H2O). It is evaluated in situ using HORAC (Hydroxyl Radical Averting Capacity) and ORAC (Oxygen Radical Absorbance Capacity) methods. The best antioxidant activity determined by HORAC method refers to Pd(5-NH2-phen)2(NO3)2. It is followed by that of 5-amino-1,10-phenanthroline and Pd(phen)2(NO3)2(H2O). The application of ORAC method shows that the best antioxidant activity is attributed to Pd(5- NH2-phen)2(NO3)2. It is followed by that of Pd(phen)2(NO3)2(H2O) and 5-amino-1,10-phenanthroline. The comparison of all results obtained leads to the conclusion that the Pd complex of 5-amino-1,10-phenanthroline shows the best antioxidant activity because of the presence of an amino group.
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    Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline
    (2012-08-01) Kaloyanov N.; Neykov M.; Wesselinova D.; Dimitrov G.
    Novel heavy metal complexes: Sr(5-NH 2-phen) 4(NO 3)(OH)(H 2O) 2 (1) (synthesized via a static self-assembly process) and Sn(phen) (NO 3)(OH)(H 2O) (2), Sn(5-NH 2-phen)(OH)(Cl)(H 2O) (3), Pb(5-NH 2-phen)(NO 3) 2(H 2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10 -2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10 -2 mg. The computed EC 50 values of 1-4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10 -3 to 6.31×10 -6 M. Towards Lep-3 substances 2-4 showed IC 50 7.52×10 -4 - 0.44 M. Substance 1 possess EC 50=1. 26×10 -7 M to the non-tumour cells. © Versita Sp. z o.o.
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    SYNTHESIS AND SPECTRAL PROPERTIES OF PALLADIUM (II) COMPLEX OF 1,4-PHENYLENE-BIS(N-1,10-PHENANTHROLYNYLMETHANIMINE)
    (2022-01-01) Neykov M.; Lozanov V.
    The synthesis of 1,4-phenylene-bis(N-1,10-phenanthrolynylmethanimine) and its Pd (II) complex is described. Their structures were confirmed using FTIR, 1H-NMR, MS, UV-Vis and ICP-OES. Based on these analysis, it can be concluded that the obtained complex is a linear coordination polymer.
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    Synthesis, spectral properties and crystal structure of calcium and strontium complexes of 1,10-phenanthroline
    (2006-07-19) Neykov M.; Van Almsick T.; Dimitrov G.
    Three new complexes of 1,10-Phenanthroline (phen), [Ca(phen) 2(H2O)2(NO3)](NO3) (1), [Sr(phen)2(H2O)2(NO3)](NO 3) (2) and [Ca(phen)2(H2O)2(NO 3)][BF4] (3) were synthesized and characterized by UV, FT IR, Raman, and MS spectra. Their crystal structures were also determined. In 1 and 2 only one of the (NO3)- is coordinated to the central atom. The other (NO3)- is away from the metal ion and was replaced by [BF4]- under the conditions of a competitive reaction. The two phenanthroline molecules also occupy nonequivalent positions showing typical π - π interactions in their crystal packing. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.