Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline
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2012-08-01
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Abstract
Novel heavy metal complexes: Sr(5-NH 2-phen) 4(NO 3)(OH)(H 2O) 2 (1) (synthesized via a static self-assembly process) and Sn(phen) (NO 3)(OH)(H 2O) (2), Sn(5-NH 2-phen)(OH)(Cl)(H 2O) (3), Pb(5-NH 2-phen)(NO 3) 2(H 2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10 -2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10 -2 mg. The computed EC 50 values of 1-4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10 -3 to 6.31×10 -6 M. Towards Lep-3 substances 2-4 showed IC 50 7.52×10 -4 - 0.44 M. Substance 1 possess EC 50=1. 26×10 -7 M to the non-tumour cells. © Versita Sp. z o.o.