Synthesis, crystal structure and biological activity screening of novel N-(α-bromoacyl)-α-amino esters containing valyl moiety

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creativework.keywordsAnti-inflammatory activity, Antibacterial activity, Cytotoxicity, N-(α bromoacyl)-αamino esters, X-ray structure
creativework.publisherSlovensko Kemijsko Drustvoen
dc.contributor.authorYancheva D.
dc.contributor.authorCherneva E.
dc.contributor.authorQuick M.
dc.contributor.authorMikhova B.
dc.contributor.authorShivachev B.
dc.contributor.authorNikolova R.
dc.contributor.authorDjordjevic A.
dc.contributor.authorUntergehrer M.
dc.contributor.authorJürgenliemk G.
dc.contributor.authorKraus B.
dc.contributor.authorSmelcerovic A.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:29Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:29Z
dc.date.issued2015-01-01
dc.description.abstractThree novel N-(α-bromoacyl)-α-amino esters: methyl 2-(2-bromo-3-methylbutanamido)pentanoate (1), methyl 2-(2-bromo-3-methylbutanamido)-2-phenylacetate (2) and methyl 2-(2-bromo-3-methylbutanamido)-3-phenylpropanoate (3) were synthesized. Single crystal X-ray diffraction data are reported for compounds 1 and 2. The cytotoxicity, antiinflammatory and antibacterial activity of compounds 1-3 were investigated. Additionally, the physico-chemical properties of studied compounds were calculated and an in silico toxicological study of compounds 1-3 was performed. The low level of cytotoxicity and absence of antibacterial and anti-inflammatory activity of 1-3 in tested concentrations might be a beneficial prerequisite for their incorporation in prodrugs.
dc.identifier.doi10.17344/acsi.2015.1418
dc.identifier.issn1318-0207
dc.identifier.scopusSCOPUS_ID:84943178048en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/347
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84943178048&origin=inward
dc.titleSynthesis, crystal structure and biological activity screening of novel N-(α-bromoacyl)-α-amino esters containing valyl moiety
dc.typeArticle
oaire.citation.issue3
oaire.citation.volume62
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