Synthesis of new modified with rhodamine b peptides for antiviral protection of textile materials

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creativework.keywordsAbsorbance, Antiviral activity, Cotton fabric, Emission, Hemorphins, Rhodamine-peptides, Virucidal effect
creativework.publisherMDPIen
dc.contributor.authorTodorov P.
dc.contributor.authorGeorgieva S.
dc.contributor.authorStaneva D.
dc.contributor.authorPeneva P.
dc.contributor.authorGrozdanov P.
dc.contributor.authorNikolova I.
dc.contributor.authorGrabchev I.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:03Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:03Z
dc.date.issued2021-11-01
dc.description.abstractHere we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3.
dc.identifier.doi10.3390/molecules26216608
dc.identifier.issn1420-3049
dc.identifier.scopusSCOPUS_ID:85118397643en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/678
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118397643&origin=inward
dc.titleSynthesis of new modified with rhodamine b peptides for antiviral protection of textile materials
dc.typeArticle
oaire.citation.issue21
oaire.citation.volume26
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