Fucoidan-Containing, Low-Adhesive Siloxane Coatings for Medical Applications: Inhibition of Bacterial Growth and Biofilm Development

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creativework.keywordsbacterial growth inhibition, fucoidan-containing, medical siloxane coatings, surface characteristics
creativework.publisherMDPIen
dc.contributor.authorVladkova T.G.
dc.contributor.authorStaneva A.D.
dc.contributor.authorAvramova I.A.
dc.contributor.authorIvanova I.A.
dc.contributor.authorGospodinova D.N.
dc.date.accessioned2024-07-10T14:27:06Z
dc.date.accessioned2024-07-10T14:50:41Z
dc.date.available2024-07-10T14:27:06Z
dc.date.available2024-07-10T14:50:41Z
dc.date.issued2023-05-01
dc.description.abstractThe deposition of low-adhesive siloxane coatings is a current trend for the non-toxic control of bacterial growth and biofilm formation. Total elimination of biofilm formation has not been reported so far. The aim of this investigation was to study the ability of a non-toxic, natural, biologically active substance, such as fucoidan, to inhibit bacterial growth on similar medical coatings. The fucoidan amount was varied, and its impact on the bioadhesion-influencing surface characteristics, as well as on bacterial cell growth, was investigated. The inclusion of up to 3–4 wt.% brown algae-derived fucoidan in the coatings increases their inhibitory effect, more significantly on the Gram-positive bacterium S. aureus than on the Gram-negative bacterium Escherichia coli. The biological activity of the studied siloxane coatings was ascribed to the formation of a low-adhesive, biologically active surface top layer consisting of siloxane oil and dispersed water-soluble fucoidan particles. This is the first report on the antibacterial activity of fucoidan-containing medical siloxane coatings. The experimental results give reason to expect that relevantly selected, natural biologically active substances can be efficient in the non-toxic control of bacterial growth on medical devices and, as a result, medical device-associated infections.
dc.identifier.doi10.3390/ma16103651
dc.identifier.issn1996-1944
dc.identifier.scopusSCOPUS_ID:85160394832en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/839
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160394832&origin=inward
dc.titleFucoidan-Containing, Low-Adhesive Siloxane Coatings for Medical Applications: Inhibition of Bacterial Growth and Biofilm Development
dc.typeArticle
oaire.citation.issue10
oaire.citation.volume16
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