In vitro antioxidant properties of 2-imino-benzimidazole and 1,3-thiazolo[3,2-a]benzimidazolone derivatives Antioksidativna aktivnost 2-imino-benzimidazol i 1,3-tiazolo[3,2-a]benzimidazolon derivata: In vitro studija

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creativework.keywords1,3-thiazolo[3,2-a]benzimidazolones, 2-imino-benzimidazoles, Antioxidant activity, Antioxidant mechanisms
creativework.publisherUniversity of Nis, Faculty of Medicineen
dc.contributor.authorTomović K.
dc.contributor.authorMrmošanin J.
dc.contributor.authorYancheva D.
dc.contributor.authorMavrova A.T.
dc.contributor.authorŠmelcerović A.
dc.date.accessioned2024-07-10T14:27:04Z
dc.date.accessioned2024-07-10T14:49:39Z
dc.date.available2024-07-10T14:27:04Z
dc.date.available2024-07-10T14:49:39Z
dc.date.issued2020-01-01
dc.description.abstractAntioxidant properties of 2-[2-imino-5-nitro-3-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-phenylethanone (compound 1) and 2-(4-fluorobenzylidene)-6-(phenylcarbonyl)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one (compound 2) were evaluated in vitro. Compounds 1 and 2 did not show significant radical scavenging activity. It has been suggested that antioxidant strategies should not be based on direct scavengers but rather on the potentiation of endogenous antioxidant defenses, or on the reduction of the sources of reactive species. Although a direct scavenging mechanism is missing, the assayed compounds (1 and 2) as evidenced inhibitors of xanthine oxidase and dipeptidyl peptidase-4 might act antioxidatively by employing other mechanisms.
dc.identifier.doi10.5937/AFMNAI37-27103
dc.identifier.issn2217-2521
dc.identifier.issn0351-6083
dc.identifier.scopusSCOPUS_ID:85102513680en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/633
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85102513680&origin=inward
dc.titleIn vitro antioxidant properties of 2-imino-benzimidazole and 1,3-thiazolo[3,2-a]benzimidazolone derivatives Antioksidativna aktivnost 2-imino-benzimidazol i 1,3-tiazolo[3,2-a]benzimidazolon derivata: In vitro studija
dc.typeArticle
oaire.citation.issue4
oaire.citation.volume37
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