Novel Peptide Analogues of Valorphin-Conjugated 1,8-Naphthalimide as Photodynamic Antimicrobial Agent in Solution and on Cotton Fabric

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creativework.keywords1,8-naphthalimide, antimicrobial, cotton fabric, light-activated, peptides, valorphin
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorStaneva D.
dc.contributor.authorTodorov P.
dc.contributor.authorGeorgieva S.
dc.contributor.authorPeneva P.
dc.contributor.authorGrabchev I.
dc.date.accessioned2024-12-04T13:38:25Z
dc.date.accessioned2024-12-04T13:47:00Z
dc.date.available2024-12-04T13:38:25Z
dc.date.available2024-12-04T13:47:00Z
dc.date.issued2024-11-01
dc.description.abstractFor the first time, N-modified analogues of VV-hemorphin-5 (Valorphin) were synthesised and conjugated with three different 4-substitured-1,8-naphthalimides (H-NVal without substituent, Cl-NVal with chloro-substituent, and NO2-NVal with nitro-substituent). Cotton fabric was modified with these peptides by soaking it in their ethanol solution, and the colourimetric properties of the obtained fabric were measured. The fluorescent analysis shows that peptide immobilisation on a solid matrix as fabric decreases the molecule flexibility and spectrum maxima shift bathocromically with the appearance of a vibrational structure. The peptides’ contact antimicrobial activity, and the resulting fabrics, have been investigated against model Gram-positive B. cereus and Gram-negative P. aeruginos bacteria. For the first time, the influence of light on bacterial inactivation was investigated by antibacterial photodynamic therapy of similar peptides. Slightly more pronounced activity in liquid media and after deposition on the cotton fabric was obtained for the peptide containing 4-nitro-1,8-naphthalimide compared to the other two peptides. Immobilisation of a peptide on the surface of fibres reduces their antimicrobial activity since their mobility is essential for good contact with bacteria. Cotton fabrics can be used in medical practice to produce antibacterial dressings and materials.
dc.identifier.doi10.3390/molecules29225421
dc.identifier.issn1420-3049
dc.identifier.scopusSCOPUS_ID:85210239709en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1578
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85210239709&origin=inward
dc.titleNovel Peptide Analogues of Valorphin-Conjugated 1,8-Naphthalimide as Photodynamic Antimicrobial Agent in Solution and on Cotton Fabric
dc.typeArticle
oaire.citation.issue22
oaire.citation.volume29
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