Study on the synthesis, characterization and bioactivities of 3-methyl-9'-fluorenespiro-5-hydantoin

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creativework.keywords3-methyl-9'-fluorenespiro-5-hydantoin, Antimicrobial effect, Cytotoxic activity, NMR spectra
creativework.publisherSlovensko Kemijsko Drustvoen
dc.contributor.authorMarinova P.
dc.contributor.authorMarinov M.
dc.contributor.authorKazakova M.
dc.contributor.authorFeodorova Y.
dc.contributor.authorSlavchev A.
dc.contributor.authorBlazheva D.
dc.contributor.authorGeorgiev D.
dc.contributor.authorPenchev P.
dc.contributor.authorSarafian V.
dc.contributor.authorStoyanov N.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:31Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:31Z
dc.date.issued2016-01-01
dc.description.abstractThis work describes a method for synthesis, as well as in vitro antiproliferative and antibacterial investigation of 3-methyl-9'-fluorenespiro-5-hydantoin. The structure of the substituted fluorenylspirohydantoin derivative was verified by UV-Vis, FT-IR, Raman, 1H NMR and 13C NMR spectroscopy, and by using a combination of 2D NMR experiments, which included 1H-1H COSY, HMQC and HMBC sequences. The geometry of the compound was optimized by the B3LYP density functional with 6-31G(d) basis set and the 1H and 13C NMR spectra were predicted with the HF/6-31G(d) calculations at the optimized geometry. The anticancer activity of the 3-methyl-9'-fluorenespiro-5-hydantoin was determined in suspension cell lines originating from tumors in humans (WERI-Rb-1). The cytotoxic effect was evaluated by WST-assay (Roche Applied Science). The antimicrobial effect of the compound against Gram-negative, Gram-positive bacteria and the yeast Candida albicans was investigated.
dc.identifier.doi10.17344/acsi.2015.1591
dc.identifier.issn1580-3155
dc.identifier.issn1318-0207
dc.identifier.scopusSCOPUS_ID:84960358714en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/368
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84960358714&origin=inward
dc.titleStudy on the synthesis, characterization and bioactivities of 3-methyl-9'-fluorenespiro-5-hydantoin
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume63
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