IMIDAZOLIDINEDIONE DERIVATIVES OF NALIDIXIC ACID: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES

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creativework.keywordsantibacterial agents, imidazolidinediones, nalidixic acid
creativework.publisherUniversity of Chemical Technology and Metallurgyen
dc.contributor.authorMarinov M.
dc.contributor.authorKostova I.
dc.contributor.authorNaydenova E.
dc.contributor.authorStoyanov N.
dc.date.accessioned2024-07-16T11:16:50Z
dc.date.accessioned2024-07-16T11:19:20Z
dc.date.available2024-07-16T11:16:50Z
dc.date.available2024-07-16T11:19:20Z
dc.date.issued2021-01-01
dc.description.abstractImidazolidine-2,4-diones (hydantoins and spirohydantoins) and nalidixic acid (1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid) are heterocyclic compounds whose ring structures include nitrogen atoms. These substances exhibit potent pharmacological activity as antitumor, antibacterial and antifungal agents, as well as aldose reductase inhibitors. This article presents the synthesis of novel heterocyclic compounds, based on the interaction of imidazolidinediones with nalidixic acid. The imidazolidinedione derivatives obtained were characterized by physicochemical parameters, elemental analysis, IR, 1H and 13C NMR spectral data. The biological activity of the synthesized products was evaluated against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the mold Aspergillus brasiliensis. All compounds showed activity against the Gram-positive and Gram-negative bacteria tested.
dc.identifier.issn1314-7978
dc.identifier.issn1314-7471
dc.identifier.scopusSCOPUS_ID:85101552632en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1309
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101552632&origin=inward
dc.titleIMIDAZOLIDINEDIONE DERIVATIVES OF NALIDIXIC ACID: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume56
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