Recent Advances in the Application of Nitro(het)aromatic Compounds for Treating and/or Fluorescent Imaging of Tumor Hypoxia

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creativework.keywordsfluorescence imaging, hypoxia, nitroaromatic compounds, tumor treatment
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorAnichina K.
dc.contributor.authorLumov N.
dc.contributor.authorBakov V.
dc.contributor.authorYancheva D.
dc.contributor.authorGeorgiev N.
dc.date.accessioned2024-09-02T14:58:15Z
dc.date.accessioned2024-09-02T15:15:26Z
dc.date.available2024-09-02T14:58:15Z
dc.date.available2024-09-02T15:15:26Z
dc.date.issued2024-08-01
dc.description.abstractThis review delves into recent advancements in the field of nitro(het)aromatic bioreductive agents tailored for hypoxic environments. These compounds are designed to exploit the low-oxygen conditions typically found in solid tumors, making them promising candidates for targeted cancer therapies. Initially, this review focused on their role as gene-directed enzyme prodrugs, which are inert until activated by specific enzymes within tumor cells. Upon activation, these prodrugs undergo chemical transformations that convert them into potent cytotoxic agents, selectively targeting cancerous tissue while sparing healthy cells. Additionally, this review discusses recent developments in prodrug conjugates containing nitro(het)aromatic moieties, designed to activate under low-oxygen conditions within tumors. This approach enhances their efficacy and specificity in cancer treatment. Furthermore, this review covers innovative research on using nitro(het)aromatic compounds as fluorescent probes for imaging hypoxic tumors. These probes enable non-invasive visualization of low-oxygen regions within tumors, providing valuable insights for the diagnosis, treatment planning, and monitoring of therapeutic responses. We hope this review will inspire researchers to design and synthesize improved compounds for selective cancer treatment and early diagnostics.
dc.identifier.doi10.3390/molecules29153475
dc.identifier.issn1420-3049
dc.identifier.scopusSCOPUS_ID:85200775659en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1464
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85200775659&origin=inward
dc.titleRecent Advances in the Application of Nitro(het)aromatic Compounds for Treating and/or Fluorescent Imaging of Tumor Hypoxia
dc.typeReview
oaire.citation.issue15
oaire.citation.volume29
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