The oxidative stress response of the filamentous yeast Trichosporon cutaneum R57 to copper, cadmium and chromium exposure

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creativework.keywordsAntioxidant defence, Biomarkers of oxidative stress, Filamentous yeast, Heavy metals, Oxidative stress
creativework.publisherDiagnosis Press Limited.michael.wagreich@univie.ac.aten
dc.contributor.authorLazarova N.
dc.contributor.authorKrumova E.
dc.contributor.authorStefanova T.
dc.contributor.authorGeorgieva N.
dc.contributor.authorAngelova M.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:06Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:06Z
dc.date.issued2014-01-01
dc.description.abstractDespite the intensive research in the past decade on the microbial bioaccumulation of heavy metals, the significance of redox state for oxidative stress induction is not completely clarified. In the present study, we examined the effect of redox-active (copper and chromium) and redox-inactive (cadmium) metals on the changes in levels of oxidative stress biomarkers and antioxidant enzyme defence in Trichosporon cutaneum R57 cells. This filamentous yeast strain showed significant tolerance and bioaccumulation capability of heavy metals. Our findings indicated that the treatment by both redox-active and redox-inactive heavy metal induced oxidative stress events. Enhanced concentrations of Cu2+, Cr6+ and Cd2+ caused acceleration in the production of reactive oxygen species (ROS), increase in the level of oxidatively damaged proteins and accumulation of reserve carbohydrates (glycogen and trehalose). Cell response against heavy metal exposure also includes elevation in the activities of antioxidant enzymes, superoxide dismutase and catalase, which are key enzymes for directly scavenging of ROS. Despite the mentioned changes in the stress biomarkers, T. cutaneum did not show a significant growth diminution. Probably, activated antioxidant defence contributes to the yeast survival under conditions of heavy metal stress.
dc.identifier.doi10.1080/13102818.2014.965020
dc.identifier.issn1310-2818
dc.identifier.scopusSCOPUS_ID:84912527108en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/322
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84912527108&origin=inward
dc.titleThe oxidative stress response of the filamentous yeast Trichosporon cutaneum R57 to copper, cadmium and chromium exposure
dc.typeArticle
oaire.citation.issue5
oaire.citation.volume28
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