SYNTHESIS, ISOLATION AND BIOLOGICAL ACTIVITY STUDIES OF GALANTHAMINE DERIVATIVES INCLUDING PEPTIDE MOIETY AND TANNINS FROM MEDICINAL PLANTS

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creativework.keywordsgalanthamine, medicinal plants, platelet aggregation, rat, RGD-peptides, tannin
creativework.publisherUniversity of Chemical Technology and Metallurgyen
dc.contributor.authorAtanasov A.
dc.contributor.authorKaradjova V.
dc.contributor.authorAndonova A.
dc.contributor.authorTsekova D.
dc.contributor.authorLozanov V.
dc.contributor.authorParashkevova B.
dc.contributor.authorMindov I.
dc.contributor.authorTodorova R.
dc.contributor.authorVezenkov L.
dc.date.accessioned2024-07-16T11:16:51Z
dc.date.accessioned2024-07-16T11:19:24Z
dc.date.available2024-07-16T11:16:51Z
dc.date.available2024-07-16T11:19:24Z
dc.date.issued2022-01-01
dc.description.abstractThe search of a new chemical substances influencing platelet aggregation is a very important endeavor for medical practice. Among the compounds that have antiaggregating activity are some peptides, tannins, etc. Here we present antiaggregation activity of Arg-Gly-Asp (RGD) peptide derivatives. Synthetic procedures of new peptide-galantamine derivatives including also glucose moiety designed to possess such activity are included. The in vitro effect of water extract from 20 tannins-containing plants from Bulgarian flora on aggregation of modified rat platelet-rich plasma was investigated and seven of them (Corylus avellana L, Cydonia oblonga Mill, Dryopteris filix-mas (L.) Schott, Ephedra distachya L., Geum urbanum L., Primula officinalis (L.) Hill and Punica granatum L.)were able to inhibit platelet aggregation
dc.identifier.issn1314-7978
dc.identifier.issn1314-7471
dc.identifier.scopusSCOPUS_ID:85123889311en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1347
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123889311&origin=inward
dc.titleSYNTHESIS, ISOLATION AND BIOLOGICAL ACTIVITY STUDIES OF GALANTHAMINE DERIVATIVES INCLUDING PEPTIDE MOIETY AND TANNINS FROM MEDICINAL PLANTS
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume57
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