An access to new N-pyrrolylcarboxylic acids as potential COX-2 inhibitors via Paal-Knorr cyclization

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creativework.keywordsCOX-2 inhibitors, Paal-Knorr cyclization, Pyrroles, Synthesis
creativework.publisherFreund Publishing House Ltdh_freund@netvision.net.ilen
dc.contributor.authorVladimirova S.
dc.contributor.authorBijev A.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:04Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:04Z
dc.date.issued2014-01-01
dc.description.abstractTwenty new N-pyrrolylcarboxylic acids were designed to assume the architecture of contemporary selective COX-2 inhibitors as potential anti-inflammatory agents. The targeted products were synthesized in 70-82% yields by Paal-Knorr cyclization of a set of eight amino acids, acting as primary amines, and four 1,4-dicarbonyl compounds. The latter substrates were prepared by C-alkylation of three commercially available β-dicarbonyl compounds with two ω-bromoacetophenones and used in situ. These compounds inhibit carrageenin-induced rat paw edema and show analgesic activity.
dc.identifier.doi10.1515/hc-2014-0022
dc.identifier.issn0793-0283
dc.identifier.scopusSCOPUS_ID:84902475689en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/312
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902475689&origin=inward
dc.titleAn access to new N-pyrrolylcarboxylic acids as potential COX-2 inhibitors via Paal-Knorr cyclization
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume20
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