In vitro and ex vivo studies on angiotensin-i converting enzyme (Ace) inhibitory activity of short synthetic peptides

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creativework.keywordsACE, Ileum contractions, Inhibitors, Peptides, Synthesis
creativework.publisherRomanian Society for Pharmaceutical Sciencesen
dc.contributor.authorYakimova B.
dc.contributor.authorMateeva P.
dc.contributor.authorKardaleva P.
dc.contributor.authorStoineva I.
dc.contributor.authorTodorova P.
dc.contributor.authorZamfirova R.
dc.contributor.authorYanev S.
dc.date.accessioned2024-08-11T12:52:34Z
dc.date.accessioned2024-08-11T12:54:03Z
dc.date.available2024-08-11T12:52:34Z
dc.date.available2024-08-11T12:54:03Z
dc.date.issued2021-01-01
dc.description.abstractIn our days the interest in the studies of new angiotensin-converting-enzyme (ACE) inhibitors as modulators of the renin-angiotensin-system (RAS) is growing, not only because of their importance as drugs for arterial hypertension treatment, but also for their therapeutic potential during COVID-19 infection. This study presents data for the design and synthesis of short peptides by SPPS strategy and investigates in vitro and ex vivo their potential as ACE inhibitors in the light of structural changes. The obtained results give insight into the structure-activity relationship of peptide sequences and show differences regarding the effects of peptides in two experimental procedures (inhibitory potency on purified ACE activity and AT-I induced rat ileum contractions). Three of the newly synthesized peptides with terminal proline, LAP, LKP and VAP, showed relatively high inhibitory activities.
dc.identifier.doi10.31925/farmacia.2021.2.16
dc.identifier.issn0014-8237
dc.identifier.scopusSCOPUS_ID:85105752032en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1447
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105752032&origin=inward
dc.titleIn vitro and ex vivo studies on angiotensin-i converting enzyme (Ace) inhibitory activity of short synthetic peptides
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume69
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