6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes

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creativework.keywords6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, Cyclodidepsipeptides, Mitochondrial membrane potential, Oxidative stress, Thymocytes cytotoxicity
dc.contributor.authorPavlovic V.
dc.contributor.authorCherneva E.
dc.contributor.authorYancheva D.
dc.contributor.authorSmelcerovic A.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:47:58Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:47:58Z
dc.date.issued2012-09-01
dc.description.abstractA study has been carried out on the potential effect of a novel cyclodidepsipeptide, 6-(propan-2-yl)-3-methyl-morpholine-2,5-dione (PMMD), on rat thymocytes. Rat thymocytes were cultivated with increasing PMMD concentrations (0.1, 1, 10 μg/well), for 24. h, and evaluated for proliferative activity, viability, reactive oxygen species and mitochondrial membrane potential. The higher PMMD concentrations inhibited thymocytes proliferative activity mainly through induction of oxidative stress and resulting cytotoxicity, without any mitochondrial membrane potential alterations in thymocytes. The obtained results are correlated with previously published data on effects of 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones on rat thymocytes. The presence of methyl group in position 4 or/and the length of alkyl chain in position 3 of 6-(propan-2-yl)-morpholine-2,5-dione core plays a role for the obtained differences in the biological response between PMMD and two previously tested 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones. © 2012 Elsevier Ltd.
dc.identifier.doi10.1016/j.fct.2012.06.004
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.scopusSCOPUS_ID:84864036253en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/249
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864036253&origin=inward
dc.title6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes
dc.typeArticle
oaire.citation.issue9
oaire.citation.volume50
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