Before or after mild acute heat exposure - does it matter for the therapy?

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creativework.keywordsheat stress, paw pressure test, pharmacodynamics, pharmacokinetics, TDIFELLK
creativework.publisherPensoft Publishersen
dc.contributor.authorSuleymanoglu Y.
dc.contributor.authorBorisova B.
dc.contributor.authorDanalev D.
dc.contributor.authorPetrov A.
dc.contributor.authorTafradjiyska R.
dc.contributor.authorNocheva H.
dc.date.accessioned2026-01-20T13:58:04Z
dc.date.accessioned2026-01-20T15:55:09Z
dc.date.available2026-01-20T13:58:04Z
dc.date.available2026-01-20T15:55:09Z
dc.date.issued2025-01-01
dc.description.abstractAdaptation to elevated temperatures poses a challenge that involves large-scale metabolic changes. It also affects the pharmacokinetics and pharmacodynamics of exogenous substances. Our experiments clearly showed differences in paw pressure thresholds in rats intraperitoneally injected with TDIFELLK-a C-terminal fragment of the calcium-binding, spermatid-specific protein 1- before and after exposure to 38.5 ± 0.5°C, compared to administration at 22 ± 2°C. Similarly, the analgesic effect of the substance, following antagonism of key analgesic receptors-namely opioid, cannabinoid, and serotonergic-was differentially influenced by heat exposure at normal temperature. The administration of the substance before heat exposure exerted a stronger effect than administration after heat exposure.
dc.identifier.doi10.3897/pharmacia.72.e152026
dc.identifier.issn0428-0296
dc.identifier.scopusSCOPUS_ID:105016689240en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1892
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105016689240&origin=inward
dc.titleBefore or after mild acute heat exposure - does it matter for the therapy?
dc.typeArticle
oaire.citation.volume72
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