Synthesis and Cytotoxicity of Platinum(II) Complexes of 3-Aminocyclopentanespiro-5-hydantoin and 3-Aminocycloheptanespiro-5-hydantoin

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creativework.keywordsAntibacterial Effect, Cytotoxic Effects, Platinum(II) Complexes
dc.contributor.authorKushev D.
dc.contributor.authorManeva L.
dc.contributor.authorGrancharov K.
dc.contributor.authorSpassovska N.
dc.contributor.authorNaydenova E.
dc.contributor.authorPopova J.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:46:56Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:46:56Z
dc.date.issued2003-01-01
dc.description.abstractFour new platinum(II) complexes of 3-aminocyclopentanespiro-5-hydantoin (acpsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were synthesized and characterized by elemental analysis, IR and 1NMR spectra. The spectral analyses indicated a cis-square planar structure of the complexes with ligands coordinated via the NH2 group. The complexes were evaluated for in vitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N, using cell-growth and macromolecular synthesis assay. The compounds, with exception of [Pt(NH3)(achpsh)Cl2] (IV), exhibited much lower cytotoxicity than that of cisplatin (DDP). Compound IV was nearly as cytotoxic as DDP. The new complexes exerted low antibacterial activity as assessed by seven bacterial strains. © 1946–2014, Verlag der Zeitschrift für Naturforschung. All rights reserved.
dc.identifier.doi10.1515/znc-2003-1-218
dc.identifier.issn0939-5075
dc.identifier.scopusSCOPUS_ID:0041696134en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/87
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0041696134&origin=inward
dc.titleSynthesis and Cytotoxicity of Platinum(II) Complexes of 3-Aminocyclopentanespiro-5-hydantoin and 3-Aminocycloheptanespiro-5-hydantoin
dc.typeArticle
oaire.citation.issue1-2
oaire.citation.volume58
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