Experimental screening for analgesic and antiinflammatory effect of novel compounds with a pyrrole heterocycle

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creativework.keywordsformalin model, paw edema, paw withdrawal, Pyrrole, tail-flick
creativework.publisherPensoft Publishersen
dc.contributor.authorZlatanova-Tenisheva H.
dc.contributor.authorVladimirova S.
dc.date.accessioned2024-07-10T14:27:06Z
dc.date.accessioned2024-07-10T14:51:33Z
dc.date.available2024-07-10T14:27:06Z
dc.date.available2024-07-10T14:51:33Z
dc.date.issued2024-01-01
dc.description.abstractThe pyrrole heterocycle is found in the chemical structure of numerous drugs with various effects, and it has a reasonably high tolerance and safety profile. The objectives of our study were to assess the analgesic and anti-inflammatory efficacy of six novel compounds with pyrrolic structures. Methods: All trials were carried out on 6-week-old male Wistar rats. Animal pain models using thermal (paw withdrawal, tail-flick) and chemical stimuli (formalin test) were used to examine antinociception. A carrageenan-induced paw edema model was used to assess anti-inflammatory activity. Results: Significant differences between the experimental groups were observed in both early and late phase of the formalin test. Conclusions: The six novel pyrrolic compounds have analgesic action against chemical stimuli in experimental conditions. They do not possess anti-inflammatory activity, or antinociceptive properties against thermal stimuli.
dc.identifier.doi10.3897/PHARMACIA.71.E121943
dc.identifier.issn0428-0296
dc.identifier.scopusSCOPUS_ID:85196971077en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/963
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196971077&origin=inward
dc.titleExperimental screening for analgesic and antiinflammatory effect of novel compounds with a pyrrole heterocycle
dc.typeArticle
oaire.citation.volume71
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