Тreatment of hepatic and pulmonary hydatidosis with albendazole and praziquantel

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creativework.keywordsalbendazole, cystic echinococcosis, hydatidosis, praziquantel
creativework.publisherSciendoen
dc.contributor.authorPopova G.
dc.contributor.authorVuchev D.
dc.contributor.authorAnichina K.
dc.date.accessioned2024-07-10T14:27:06Z
dc.date.accessioned2024-07-10T14:51:06Z
dc.date.available2024-07-10T14:27:06Z
dc.date.available2024-07-10T14:51:06Z
dc.date.issued2023-09-01
dc.description.abstractConservative treatment of human hydatidosis (cystic echinococcosis) with albendazole has improved significantly the prognosis of the disease. But its therapeutic effectiveness is 30 – 70 %. Тhere is some evidence that the effectiveness of albendazole can be enhanced by praziquantel but there is no strict recommendation for the use of praziquantel as part of long-term drug therapy for hydatidosis. The aim of the study was to evaluate the effectiveness of the combination of albendazole and praziquantel in patients with hepatic and/or pulmonary hydatidosis. A total of 20 patients (aged 12 – 70 years old) were included in the study for a 5-year period. Fourteen patients (70 %) were with hepatic hydatidosis, 4 (20 %) with pulmonary and 2 (10 %) with hepatic and pulmonary hydatidosis. They were treated with albendazole (15 mg/kg/day) and praziquantel (40 mg/kg/weekly) for 2 – 9 one-month courses. The result of the therapy was followed using imaging (abdominal ultrasound, lung radiography, computed tomography) and serology. Seventeen (85 %) out of 20 patients showed evidence of response on imaging defined as improvement or cure of hydatid cysts. Seven (35 %) of the patients with multiple cystic echinococcosis took praziquantel once a week for 6 months. Only 3 patients (15 %) with multiple hydatidosis (2 with liver and 1 with pulmonary hydatidosis) failed to respond to the therapy with both drugs. No side effects have been reported by the patients. The combination of albendazole and praziquantel seems to be an option to improve the therapeutic effеctiveness of the conservative treatment of cystic echinococcosis.
dc.identifier.doi10.2478/helm-2023-0028
dc.identifier.issn1336-9083
dc.identifier.issn0440-6605
dc.identifier.scopusSCOPUS_ID:85181558034en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/894
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85181558034&origin=inward
dc.titleТreatment of hepatic and pulmonary hydatidosis with albendazole and praziquantel
dc.typeArticle
oaire.citation.issue3
oaire.citation.volume60
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