Analgesic properties of newly synthesized N-pyrrolyl hydrazide hydrazones

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creativework.keywordsAnalgesic activity, Hydrazides, Hydrazones, Pyrrole
creativework.publisherUniversity of Beninen
dc.contributor.authorNocheva H.
dc.contributor.authorVladimirova S.
dc.contributor.authorTzankova D.
dc.contributor.authorPeikova L.
dc.contributor.authorGeorgieva M.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:33Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:33Z
dc.date.issued2023-01-01
dc.description.abstractPurpose: To screen a series of newly synthesized N-pyrrolyl hydrazide hydrazones for analgesic activity via Paw-pressure (PP) test and hot plate test (HPT). Methods: The compounds newly synthesized through the classical Paal-Knor cyclization, N-pyrrolyl hydrazide-hydrazones were administered intraperitoneally at a dose of 20 mg/kg. Paw pressure and hot plate tests were applied to assess the analgesic properties. In addition, stress-induced analgesia with naloxone as a non-selective opioid receptor antagonist was performed. Results: The compound (DI-5g), containing an izatine carbonyl fragment, was the most promising. It presented the highest paw pressure threshold (25 AU at 30th min) by exceeding the analgesic activity of the referent metamizole (23 AU at 30th min). The relative effect from the hot plate test was consistent with the paw pressure results. Opioid receptors were involved in the analgesic activities of N-pyrrolyl hydrazide-hydrazones. Conclusion: The N-pyrrolyl carboxylic acids are synthesized and identified as new compounds and their hydrazide-hydrazone derivatives as promising leads for future design and synthesis of drugs with possibly prolonged analgesic activity.
dc.identifier.doi10.4314/tjpr.v22i1.17
dc.identifier.issn1596-9827
dc.identifier.issn1596-5996
dc.identifier.scopusSCOPUS_ID:85147518183en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/784
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147518183&origin=inward
dc.titleAnalgesic properties of newly synthesized N-pyrrolyl hydrazide hydrazones
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume22
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