Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

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creativework.keywordsantibacterial activity, antioxidant activity, L. libyca, mineral content, molecular docking, total flavonoid, total phenol content
creativework.publisherMDPIen
dc.contributor.authorBenchikha N.
dc.contributor.authorChelalba I.
dc.contributor.authorDebbeche H.
dc.contributor.authorMessaoudi M.
dc.contributor.authorBegaa S.
dc.contributor.authorLarkem I.
dc.contributor.authorAmara D.G.
dc.contributor.authorRebiai A.
dc.contributor.authorSimal-Gandara J.
dc.contributor.authorSawicka B.
dc.contributor.authorAtanassova M.
dc.contributor.authorYoussef F.S.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:09Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:09Z
dc.date.issued2022-08-01
dc.description.abstractLobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase binding sites. Thus, it can be concluded that L. libyca can serve as a beneficial nutraceutical agent, owing to its significant antioxidant and antibacterial potential and due to its richness in iron, calcium and potassium, which are essential for maintaining a healthy lifestyle.
dc.identifier.doi10.3390/molecules27123744
dc.identifier.issn1420-3049
dc.identifier.scopusSCOPUS_ID:85131693022en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/723
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131693022&origin=inward
dc.titleLobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies
dc.typeArticle
oaire.citation.issue12
oaire.citation.volume27
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