Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review

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creativework.keywordsbiological activities, metal complexes, peptides
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorMarinova P.
dc.contributor.authorTamahkyarova K.
dc.date.accessioned2024-09-02T14:58:15Z
dc.date.accessioned2024-09-02T15:15:26Z
dc.date.available2024-09-02T14:58:15Z
dc.date.available2024-09-02T15:15:26Z
dc.date.issued2024-06-01
dc.description.abstractPeptides, both natural and synthetic, are well suited for a wide range of purposes and offer versatile applications in different fields such as biocatalysts, injectable hydrogels, tumor treatment, and drug delivery. The research of the better part of the cited papers was conducted using various database platforms such as MetalPDB. The rising prominence of therapeutic peptides encompasses anticancer, antiviral, antimicrobial, and anti-neurodegenerative properties. The metals Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn, and Mo are ten of the twenty elements that are considered essential for life. Crucial for understanding the biological role of metals is the exploration of metal-bound proteins and peptides. Aside from essential metals, there are other non-essential metals that also interact biologically, exhibiting either therapeutic or toxic effects. Irregularities in metal binding contribute to diseases like Alzheimer’s, neurodegenerative disorders, Wilson’s, and Menkes disease. Certain metal complexes have potential applications as radiopharmaceuticals. The examination of these complexes was achieved by preforming UV–Vis, IR, EPR, NMR spectroscopy, and X-ray analysis. This summary, although unable to cover all of the studies in the field, offers a review of the ongoing experimentation and is a basis for new ideas, as well as strategies to explore and gain knowledge from the extensive realm of peptide-chelated metals and biotechnologies.
dc.identifier.doi10.3390/biotech13020009
dc.identifier.issn2673-6284
dc.identifier.scopusSCOPUS_ID:85196798965en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1461
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196798965&origin=inward
dc.titleSynthesis and Biological Activities of Some Metal Complexes of Peptides: A Review
dc.typeReview
oaire.citation.issue2
oaire.citation.volume13
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