Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line

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creativework.keywords(9′-fluorene)-spiro-5-(2-thiohydantoin), (9′-fluorene)-spiro-5-hydantoin, Cytotoxic/antiproliferative effects, Fluorenylspirohydantoins, Metal complexes
creativework.publisherDiagnosis Press Limited.diagnosis@ibn.bgen
dc.contributor.authorMarinova P.
dc.contributor.authorMarinov M.
dc.contributor.authorKazakova M.
dc.contributor.authorFeodorova Y.
dc.contributor.authorPenchev P.
dc.contributor.authorSarafian V.
dc.contributor.authorStoyanov N.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:05Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:05Z
dc.date.issued2014-01-01
dc.description.abstractThis paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet-visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and 1H- and 13C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1. © 2014 The Author(s). Published by Taylor & Francis.
dc.identifier.doi10.1080/13102818.2014.910363
dc.identifier.issn1310-2818
dc.identifier.scopusSCOPUS_ID:84905904598en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/316
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905904598&origin=inward
dc.titleSynthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume28
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