Synthesis of N-[1-(2-Acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and Its Copper(II) Complex

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creativework.keywordscomplexation, copper(II) complexes, in silico prediction, ketoamides
creativework.publisherPleiades Publishingen
dc.contributor.authorMarinova P.
dc.contributor.authorNikolova S.
dc.contributor.authorTsoneva S.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:35Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:35Z
dc.date.issued2023-01-01
dc.description.abstractAbstract: This paper represents a convenient method for the synthesis of N-[1-(2-acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and its Cu(II) complex. In silico analysis predicted spasmolytic activity for the compound. Based on the in silico calculations, the importance of the predicted ketoamide, and our previous experiments, we synthesized the ketoamide via ortho-acylation of N-[1-(3,4-dimethoxyphenyl)propan-2-yl]benzamide with acetic anhydride in polyphosphoric acid. We applied the title ketoamide in reaction with Cu(II) varying the solvents. We found that the reaction leads to the formation of a coordination compound when the ligand dissolved in DMSO reacts with a water solution of CuCl2 in an alkaline environment in a molar ratio M : L : OH– = 1 : 2 : 2. The structures of the new compounds are discussed based on their melting points, IR, 1H, 13C NMR and Raman spectral data.
dc.identifier.doi10.1134/S1070363223010218
dc.identifier.issn1608-3350
dc.identifier.issn1070-3632
dc.identifier.scopusSCOPUS_ID:85149830214en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/799
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149830214&origin=inward
dc.titleSynthesis of N-[1-(2-Acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and Its Copper(II) Complex
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume93
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