Recent Progress in Terrestrial Biota Derived Antibacterial Agents for Medical Applications

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creativework.keywordsantibacterial compounds, antibacterial products, bacteriocines, biosynthesized nanoparticles, combination treatments, terrestrial biota
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorVladkova T.G.
dc.contributor.authorSmani Y.
dc.contributor.authorMartinov B.L.
dc.contributor.authorGospodinova D.N.
dc.date.accessioned2024-11-13T14:47:19Z
dc.date.accessioned2024-11-14T07:26:04Z
dc.date.available2024-11-13T14:47:19Z
dc.date.available2024-11-14T07:26:04Z
dc.date.issued2024-10-01
dc.description.abstractConventional antibiotic and multidrug treatments are becoming less and less effective and the discovery of new effective and safe antibacterial agents is becoming a global priority. Returning to a natural antibacterial product is a relatively new current trend. Terrestrial biota is a rich source of biologically active substances whose antibacterial potential has not been fully utilized. The aim of this review is to present the current state-of-the-art terrestrial biota-derived antibacterial agents inspired by natural treatments. It summarizes the most important sources and newly identified or modified antibacterial agents and treatments from the last five years. It focuses on the significance of plant- animal- and bacteria-derived biologically active agents as powerful alternatives to antibiotics, as well as the advantages of utilizing natural antibacterial molecules alone or in combination with antibiotics. The main conclusion is that terrestrial biota-derived antibacterial products and substances open a variety of new ways for modern improved therapeutic strategies. New terrestrial sources of known antibacterial agents and new antibacterial agents from terrestrial biota were discovered during the last 5 years, which are under investigation together with some long-ago known but now experiencing their renaissance for the development of new medical treatments. The use of natural antibacterial peptides as well as combinational therapy by commercial antibiotics and natural products is outlined as the most promising method for treating bacterial infections. In vivo testing and clinical trials are necessary to reach clinical application.
dc.identifier.doi10.3390/molecules29204889
dc.identifier.issn1420-3049
dc.identifier.scopusSCOPUS_ID:85207674114en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1531
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85207674114&origin=inward
dc.titleRecent Progress in Terrestrial Biota Derived Antibacterial Agents for Medical Applications
dc.typeReview
oaire.citation.issue20
oaire.citation.volume29
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