Comparative Analysis of Anticonvulsant Activity of Trans and Cis 5,5′-Diphenylhydantoin Schiff Bases

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creativework.keywords5,5′-diphenylhydantoin Schiff bases, KA SE, MES, mice, trans–cis
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorTchekalarova J.
dc.contributor.authorTodorov P.
dc.contributor.authorStoyanova T.
dc.contributor.authorAtanasova M.
dc.date.accessioned2024-07-10T14:27:06Z
dc.date.accessioned2024-07-10T14:51:05Z
dc.date.available2024-07-10T14:27:06Z
dc.date.available2024-07-10T14:51:05Z
dc.date.issued2023-11-01
dc.description.abstractRecently, the four 5,5′-diphenylhydantoin Schiff bases, possessing different aromatic species (SB1-Ph, SB2-Ph, SB3-Ph and SB4-Ph) were synthesized, characterized, and evaluated for anticonvulsant activity in combination with phenytoin. In the present study, the SB1-Ph and SB4-Ph compounds were selected, based on their anticonvulsant potency, and compared with their cis isomers, prepared after a one-hour exposure to the UV source, for their anticonvulsant potency in the maximal electroshock (MES) test and the kainate (KA)-induced status epilepticus (SE) test in mice. In the MES test, the cis SB1-Ph compound exhibited superior to phenytoin and trans isomer activity in the three tested doses, while the cis SB4-Ph compound entirely suppressed the electroshock-induced seizure spread at the highest dose of 40 mg/kg. Pretreatment with the cis SB1-Ph compound and the cis SB4-Ph at the doses of 40 mg/kg, respectively, for seven days, significantly attenuated the severity of KA SE compared to the matched control group pretreated with a vehicle, while phenytoin was ineffective in this test. The cis SB4-Ph but not the cis SB1-Ph demonstrated an antioxidant effect against the KA-induced SE in the hippocampus. Our results suggest that trans–cis conversion of 5,5′-diphenylhydantoin Schiff bases has potential against seizure spread in the MES test and mitigated the KA-induced SE. The antioxidant potency of cis SB4-Ph might be associated with its efficacy in mitigating the SE.
dc.identifier.doi10.3390/ijms242216071
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopusSCOPUS_ID:85177744730en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/884
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85177744730&origin=inward
dc.titleComparative Analysis of Anticonvulsant Activity of Trans and Cis 5,5′-Diphenylhydantoin Schiff Bases
dc.typeArticle
oaire.citation.issue22
oaire.citation.volume24
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