EVALUATION OF THE IN VITRO NEUROTOXIC AND NEUROPROTECTIVE EFFECTS AT CELLULAR AND SUBCELLULAR LEVELS OF NEWLY SYNTHESIZED N-PYRROLYL HYDRAZONES

Simple item page
creativework.keywordsantioxidant activity, N-pyrrolyl hydrazones, neuroprotection, SH-SY5Y
creativework.publisherRomanian Society for Pharmaceutical Sciencesen
dc.contributor.authorTzankova D.
dc.contributor.authorVladimirova S.
dc.contributor.authorStefanova D.
dc.contributor.authorPeikova L.
dc.contributor.authorKondeva-Burdina M.
dc.contributor.authorGeorgieva M.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:31Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:31Z
dc.date.issued2022-01-01
dc.description.abstractThe study presents the safety, antioxidant activity and neuroprotective effects of a series of newly synthesized N-pyrrolyl hydrazide-hydrazones (5, 5a-g) in two in vitro models: human neuronal cells SH-SY5Y and isolated rat brain synaptosomes. The performed in vitro toxicological evaluation in neuronal SH-SY5Y cell line models determined the lowest cytotoxicity and best safety profile for compound 5a, followed by 5d on both evaluated parameters. The protective effect of the newly synthesized hydrazone 5a was found to be comparable to melatonin used as a standard. The obtained results indicate that the presence of pyrrole ring, containing multiple phenyl nuclei and hydrazide-hydrazone group in the side chain, leads to increase in the antioxidant effect.
dc.identifier.doi10.31925/farmacia.2022.5.12
dc.identifier.issn0014-8237
dc.identifier.scopusSCOPUS_ID:85140826249en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/750
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85140826249&origin=inward
dc.titleEVALUATION OF THE IN VITRO NEUROTOXIC AND NEUROPROTECTIVE EFFECTS AT CELLULAR AND SUBCELLULAR LEVELS OF NEWLY SYNTHESIZED N-PYRROLYL HYDRAZONES
dc.typeArticle
oaire.citation.issue5
oaire.citation.volume70
Files
Collections
Articles