pH-dependent hydrogels obtained by low molecular weight derivatives of aspartic acid and glutamic acid (L-Asp and L-Glu)

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creativework.keywordsAgNPs release, Aspartic acid (L-Asp), Gemini surfactants, Glutamic acid (L-Glu), Low molecular weight gelator, pH-dependent hydrogels
creativework.publisherElsevier B.V.en
dc.contributor.authorTsekova D.
dc.contributor.authorKondova V.
dc.contributor.authorDochev K.
dc.contributor.authorAnchev B.
dc.date.accessioned2024-11-13T14:47:19Z
dc.date.accessioned2024-11-14T07:26:03Z
dc.date.available2024-11-13T14:47:19Z
dc.date.available2024-11-14T07:26:03Z
dc.date.issued2024-01-01
dc.description.abstractWe report here the synthesis of two new anionic gemini surfactants, derivatives of L-Asp and L-Glu with analogous structure and their applications as low molecular weight gelators. Conditions for formation of pH-dependent hydrogels and their stability are presented and discussed. Although both compounds possess very close molecular structures, only one of them – the derivative of L-Asp, can form stable hydrogels. Loading of such a hydrogel with silver nanoparticles and the conditions of their release are also studied and described. Different methods to analyze molecular and supramolecular structures, such as NMR, FTIR, UV–VIS and SEM, are used to characterize the compounds and also to understand and follow the processes of loading and release of silver nanoparticles. It was found that a stable hydrogel can be formed only in acidic solution, while release can happen only at basic condition – over pH ≥ 9. The results obtained show that such pH-dependent hydrogels can be used for slowly and gradually supply of active compounds at necessity, expressed through changing the pH of the living tissue.
dc.identifier.doi10.1016/j.crbiot.2024.100257
dc.identifier.issn2590-2628
dc.identifier.scopusSCOPUS_ID:85206185133en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1526
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85206185133&origin=inward
dc.titlepH-dependent hydrogels obtained by low molecular weight derivatives of aspartic acid and glutamic acid (L-Asp and L-Glu)
dc.typeArticle
oaire.citation.volume8
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