Attenuation of 1-chloro-2, 4-dinitrobenzene-induced inflammation in atopic dermatitis-like skin lesions in rats by a pyrrole containing FELL-NH2 bioconjugate: Cannabinoid receptor type 1 involvement

Simple item page
creativework.keywordsanandamide, atopic dermatitis, bioconjugates, CB1 expression, FELL, immunohistochemistry, peptides, rat model
creativework.publisherPensoft Publishersen
dc.contributor.authorPapadakis K.
dc.contributor.authorBezirci K.
dc.contributor.authorBorisova B.
dc.contributor.authorVladimirova S.
dc.contributor.authorDanalev D.
dc.contributor.authorHandjieva-Darlenska T.
dc.contributor.authorTafradjiiska-Hadjiolova R.
dc.contributor.authorNocheva H.
dc.date.accessioned2024-11-13T14:47:19Z
dc.date.accessioned2024-11-14T07:26:03Z
dc.date.available2024-11-13T14:47:19Z
dc.date.available2024-11-14T07:26:03Z
dc.date.issued2024-01-01
dc.description.abstractAtopic dermatitis (AD) is a chronic inflammatory skin condition of significant health and social importance, which justifies the search for new means of treatment. Since the endogenous cannabinoid system appears to be involved in the pathogenesis of AD, the proposed article summarizes the clinical impact on skin inflammation in a rat model of 1-chloro-2, 4-dinitrobenzene-induced atopic dermatitis-like condition after exogenous systemic administration of the cannabinoid receptor type 1 (CB1r) agonist anandamide, as well as after local treatment with a newly synthesized pyrrole moiety containing bioconjugate of FELL tetrapeptide with CB1r-dependent analgesic activity. The changes in skin lesions and ear thickness were estimated along with the CB1r expression immunohistochemically determined on skin punch biopsies. The results showed attenuation of skin lesions by anandamide and lack of positive effect after introduction of CB1r antagonist, accompanied by a change in CB1r expression, suggesting the involvement of the cannabinoid system in the defensive functions of the skin. The topically applied newly synthesized bioconjugate also favorably affected skin manifestations of inflammation, but without a change in CB1r expression, suggesting the involvement of other mechanisms in the reported effects.
dc.identifier.doi10.3897/pharmacia.71.e130213
dc.identifier.issn0428-0296
dc.identifier.scopusSCOPUS_ID:85205813402en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1524
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85205813402&origin=inward
dc.titleAttenuation of 1-chloro-2, 4-dinitrobenzene-induced inflammation in atopic dermatitis-like skin lesions in rats by a pyrrole containing FELL-NH2 bioconjugate: Cannabinoid receptor type 1 involvement
dc.typeArticle
oaire.citation.volume71
Files
Collections
Articles