In vitro Assessment of the Lipid Peroxidation of N,N'-Disubstituted Benzimidazole-2-Thiones: Hydrazides vs Esters

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creativework.keywordsantioxidant activity, lipid peroxidation, N,N'-disubstituted benzimidazole-2-thiones
creativework.publisherUniversity of Nis, Faculty of Medicineen
dc.contributor.authorLazarević J.
dc.contributor.authorZvezdanović J.
dc.contributor.authorAnastassova N.
dc.contributor.authorMavrova A.T.
dc.contributor.authorYancheva D.
dc.contributor.authorŠmelcerović A.
dc.date.accessioned2024-07-10T14:27:05Z
dc.date.accessioned2024-07-10T14:50:33Z
dc.date.available2024-07-10T14:27:05Z
dc.date.available2024-07-10T14:50:33Z
dc.date.issued2022-01-01
dc.description.abstractIntroduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. Material and methods: In the present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) and hydrazide (5 - 7) side chains were investigated for in vitro antioxidant activity using lipid peroxidation method. Results: Among the assayed compounds, three hydrazides, 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-1,3- dihydro-2H-benzimidazole-2-thione (5), 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-methyl-1,3-dihydro-2Hbenzimidazole- 2-thione (6) and 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-benzoyl-1,3-dihydro-2Hbenzimidazole- 2-thione (7) showed good antioxidant properties (IC50 < 100 μM), with the best lipid peroxidation inhibition values (IC50) shown for compound 5 (64 ± 10 μM) and compound 6 (73 ± 29 μM). Conclusion: Indicated hydrazide structures may constitute a sort of molecular basis, a promising starting point for the development of compounds for the prevention and treatment of diseases resulting from oxidative damage.
dc.identifier.doi10.5937/afmnai39-36399
dc.identifier.issn2217-2521
dc.identifier.issn0351-6083
dc.identifier.scopusSCOPUS_ID:85148094933en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/785
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148094933&origin=inward
dc.titleIn vitro Assessment of the Lipid Peroxidation of N,N'-Disubstituted Benzimidazole-2-Thiones: Hydrazides vs Esters
dc.typeArticle
oaire.citation.issue4
oaire.citation.volume39
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