Determination of radical scavenging activity of Creatine lysinate against methanol solutions of ABTS

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creativework.keywordsABTS, Antitradical power, Creatine lysinate, Index of inhibition, Trolox
creativework.publisherSPER Publicationsen
dc.contributor.authorTsvetkova D.
dc.contributor.authorKostadinova I.
dc.contributor.authorVezenkov L.
dc.contributor.authorMarinov L.
dc.date.accessioned2024-07-10T14:27:06Z
dc.date.accessioned2024-07-10T14:51:04Z
dc.date.available2024-07-10T14:27:06Z
dc.date.available2024-07-10T14:51:04Z
dc.date.issued2023-01-01
dc.description.abstractDietrary Creatine supplements can exert benefits against muscular dystrophic diseases, such as Duchenne muscular dystrophy, myophosphorylase deficiency (McArdle's disease), and fibromyalgia and can provide protection towards neurodegenerative disorders as Huntington, Parkinson and Amyotrophic lateral sclerosis. Creatine supplementation improves cognition and memory and can promote muscle strength. Creatine plays an important role in maintaining heart function in congestive heart failure. The current investigation's goal was to learn more about the ability of creatine lysinate to scavenge ABTS-radicals. Radiation scavenging activity [%], idex of inhibition (IC50), antioxidant power (1/IC50), and Trolox equivalent activity were calculated using the reduction in the absorbance at = 744 nm of the methanol solution of the ABTS-radical. Creatine lysinate (IC50 = 62.8 mM) exhibits an antiradical action, as shown by the experimental findings. According to the available data, creatine lysinate is less active than trolox (IC50 = 0.2 mM), which is because it has a greater IC50 value and less antioxidant capacity (1/IC50, = 0.016) than trolox (1/IC50, = 5). In current investigation was confirmed that ABTS-radical scavenging effect of Creatine lysinate is higher in comparison with Creatine monohydrate (IC50 = 100.98 mM), which was proven by the obtained higher Trolox equivalent antioxidant capacity TEAC = 0.003 of Creatine lysinate, compared with that of Creatine monohydrate (TEAC = 0.002).
dc.identifier.doi10.51847/Y35ODXRLW0
dc.identifier.issn2249-3379
dc.identifier.scopusSCOPUS_ID:85175253351en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/874
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85175253351&origin=inward
dc.titleDetermination of radical scavenging activity of Creatine lysinate against methanol solutions of ABTS
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume13
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