Investigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes

Simple item page
creativework.keywords2,4-dithiouracil, antimicrobial activity, copper(II) complexes, gold(III) complexes
creativework.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.contributor.authorMarinova P.
dc.contributor.authorStoitsov D.
dc.contributor.authorBurdzhiev N.
dc.contributor.authorTsoneva S.
dc.contributor.authorBlazheva D.
dc.contributor.authorSlavchev A.
dc.contributor.authorVarbanova E.
dc.contributor.authorPenchev P.
dc.date.accessioned2024-09-02T14:58:15Z
dc.date.accessioned2024-09-02T15:15:26Z
dc.date.available2024-09-02T14:58:15Z
dc.date.available2024-09-02T15:15:26Z
dc.date.issued2024-08-01
dc.description.abstractThe goal of this study is to synthesize, determine the structure, and examine the antimicrobial properties of novel Cu(II) and Au(III) complexes of 2,4-dithiouracil and its derivatives. These complexes were obtained by mixing aqueous solutions of the corresponding metal salts with the ligand dissolved in DMSO and aqueous NaOH, using a metal-to-ligand ratio of 1:4:2. The structures of the new compounds were analyzed by melting point determination, microwave plasma atomic emission spectrometry (MP-AES) for Cu and Au, inductively coupled plasma optical emission spectrometry (ICP-OES) for S, attenuated total reflection (ATR), solution and solid-state NMR, and Raman spectroscopy. The data for 2,4-dithiouracil obtained from the 1H NMR, 13C NMR, distortionless enhancement by polarization transfer spectrum (DEPT-135), proton–proton homonuclear correlation spectrum (1H-1H COSY), long-range 1H-13C heteronuclear multiple bond correlation experiment (HMBC), and heteronuclear single quantum coherence spectra (HSQC) aided the interpretation of the NMR data for the gold and copper complexes. Furthermore, the antimicrobial effect of the free ligands and their complexes was assessed against Gram-positive and Gram-negative bacteria, as well as yeasts.
dc.identifier.doi10.3390/app14156601
dc.identifier.issn2076-3417
dc.identifier.scopusSCOPUS_ID:85200861509en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1466
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85200861509&origin=inward
dc.titleInvestigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes
dc.typeArticle
oaire.citation.issue15
oaire.citation.volume14
Files
Collections
Articles