ANTIMICROBIAL ACTIVITIES OF AMPHIPHILIC DERIVATIVES OF α-AMINO ACIDS
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2023-01-01
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Abstract
Antimicrobial products are very important to the health of the society. The increasing resistance of some bacteria to existing antimicrobials require searching of new active substances with antimicrobial activities. This review is devoted to the newly synthesised amphiphilic derivatives of proteinogenic a-amino acids and study of their antimicrobial properties. For this purpose, classification of the basis of both - head charge and type of the amino acid is presented with focus on the cationic representatives as possessing well-expressed antimicrobial activities. Data about representatives of amphiphilic alpha-amino acid derivatives with proven antimicrobial activity has been summarised, presented in tables and compared. Results obtained up to now show that arginine derivatives are the most promising, but also gemini derivatives of lysine and arginine amphiphiles have higher antimicrobial activity then monomeric ones. Even though these compounds have lower toxicity thаn conventional surfactants, they are still more toxic than accepted for drug formulations, so to be used in terms of antibiotics. Characteristics of the newly designed alpha-amino acid amphiphilic derivatives should be improved before their antimicrobial potential becomes practically applicable.