Synthesis and antimicrobial activity of 1,8-naphthalimide derivatives of nalidixic acid

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creativework.keywords1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-diones, Gram-negative bacteria, Gram-positive bacteria
creativework.publisherUniversity of Chemical Technology and Metallurgyjournal@uctm.eduen
dc.contributor.authorMarinov M.
dc.contributor.authorKostova I.
dc.contributor.authorNaydenova E.
dc.contributor.authorStoyanov N.
dc.date.accessioned2024-07-16T11:16:49Z
dc.date.accessioned2024-07-16T11:18:57Z
dc.date.available2024-07-16T11:16:49Z
dc.date.available2024-07-16T11:18:57Z
dc.date.issued2019-01-01
dc.description.abstractVarious naphthalimides are synthesized and their biological activity is studied. The target compounds are prepared by the interaction of different substituted 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-diones with nalidixic acid (1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid). The structures of all synthesized products are verified via their physicochemical parameters, an elemental analysis, IR, 1H and 13C NMR spectroscopy. The antimicrobial activity of the compounds obtained is determined against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Essherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the molds Penicillium chrysogenum and Aspergillus niger. It is found that N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide, N-(6-1H-indol-3-yl-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide and N-(6-piperidin-1-yl-1,3-dioxo-1H-benzo[de] isoquinolin-2(3H)-yl)-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide are active against the Gram-positive and Gram-negative bacteria tested.
dc.identifier.issn1314-7978
dc.identifier.issn1314-7471
dc.identifier.scopusSCOPUS_ID:85076572711en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1265
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076572711&origin=inward
dc.titleSynthesis and antimicrobial activity of 1,8-naphthalimide derivatives of nalidixic acid
dc.typeArticle
oaire.citation.issue6
oaire.citation.volume54
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