Effects on MC3T3-E1 cells and in silico toxicological study of two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones

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creativework.keywordsCyclodidepsipeptides, In silico toxicological study, MC3T3-E1 cells
creativework.publisherNatural Product Incorporationen
dc.contributor.authorVukelić-Nikolić M.
dc.contributor.authorKolarević A.
dc.contributor.authorTomović K.
dc.contributor.authorYancheva D.
dc.contributor.authorCherneva E.
dc.contributor.authorNajman S.
dc.contributor.authorSmelcerović A.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:30Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:30Z
dc.date.issued2015-08-01
dc.description.abstractRecently, we found that two cyclodidepsipeptides, 3,6-di-(propan-2-yl)-4-methyl-morpholine-2,5-dione (1) and 3-(2-methylpropyl)-6-(propan-2-yl)-4-methylmorpholine-2,5-dione (2), are excellent inhibitors of xanthine oxidase. In order to obtain more information about the toxicological potential of compounds 1 and 2 on bone cells, the current study was designed to evaluate the effect of these compounds on viability and proliferation of MC3T3-E1 cells. Compound 1 showed neither cytotoxic nor stimulatory effect on cell viability, while compound 2 showed a slight stimulatory effect on cell viability. Both studied compounds showed slight stimulatory effects on proliferation of MC3T3-E1 cells, in a dose dependent manner. Additionally, an in silico toxicological study of compounds 1 and 2 was performed, and the results indicate that they have a good probability of safe biological intake.
dc.identifier.doi10.1177/1934578x1501000828
dc.identifier.issn1555-9475
dc.identifier.issn1934-578X
dc.identifier.scopusSCOPUS_ID:84945989058en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/355
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84945989058&origin=inward
dc.titleEffects on MC3T3-E1 cells and in silico toxicological study of two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones
dc.typeArticle
oaire.citation.issue8
oaire.citation.volume10
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